Title : Dissociation of heparin-dependent thrombin and factor Xa inhibitory activities of antithrombin-III by mutations in the reactive site.

Pub. Date : 1993 Apr 25

PMID : 8473344






1 Functional Relationships(s)
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1 In fact, point mutation of the P1" site from Ser (present in AT-III) to Ile (present in prothrombin) is sufficient to dissociate heparin-dependent thrombin and Factor Xa inhibitory activities. Isoleucine coagulation factor II, thrombin Homo sapiens