Title : Effect of Losartan, a nonpeptide angiotensin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin.

Pub. Date : 1993 Apr

PMID : 8456103






2 Functional Relationships(s)
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1 Intracerebroventricular administration of renin reduces urine volume and increases sodium excretion and water intake in conscious, male, hydrated rats. Water renin Rattus norvegicus
2 Peripheral and central administration of the AT1 receptor blocker significantly lengthened the onset of drinking behavior and reduced the cumulative water intake observed after intracerebroventricular injection of renin. Water renin Rattus norvegicus