Title : Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

Pub. Date : 1993 Mar 25

PMID : 8454631






1 Functional Relationships(s)
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1 Aspirin completely inhibited bis-oxygenation of arachidonate by PGH synthase-1; in contrast, aspirin-treated PGH synthase-2 metabolized arachidonate primarily to 15-hydroxyeicosatetraenoic acid (15-HETE) instead of PGH2. Eicosatetraenoic acid, 15-hydroxy- prostaglandin-endoperoxide synthase 2 Mus musculus