Protein Name prostaglandin-endoperoxide synthase 2
Organism Mus musculus
Gene ID 19225
Gene Symbol

Ptgs2

UniProt Q05769 (PGH2_MOUSE)
Relationships Total Number of functionally related compound(s) : 1538
Total Number of Articles : 2543
Description

prostaglandin-endoperoxide synthase 2

Gene Summary

This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]

synonyms
  • prostaglandin G/H synthase 2
  • PGH synthase 2
  • cyclooxygenase-2
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Properties