Title : Evidence of stimulation of the gamma-aminobutyric acid shunt by valproate and E-delta 2-valproate in neonatal rat brain.

Pub. Date : 1993 Mar

PMID : 8450838






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Brain glutamate decarboxylase activity was significantly increased after incubation of the brain slices in the presence of valproate. Valproic Acid glutamate-ammonia ligase Rattus norvegicus
2 Consequently, our results suggest that the mechanism of action of valproate is related to the increase in the levels of the inhibitory neurotransmitter GABA caused by the enhancement of flux through the glutamate decarboxylase-catalyzed reaction. Valproic Acid glutamate-ammonia ligase Rattus norvegicus