Pub. Date : 1993 Mar
PMID : 8441380
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The CDC25 fusion protein catalyzed replacement of GDP-bound to Ras2 with GTP (activation) more efficiently than that of the reverse reaction of replacement of GTP for GDP (deactivation), consistent with prior genetic analysis of CDC25 which indicated a positive role in the activation of Ras. | Guanosine Diphosphate | Ras family guanine nucleotide exchange factor CDC25 | Saccharomyces cerevisiae S288C |
| 2 | The CDC25 fusion protein catalyzed replacement of GDP-bound to Ras2 with GTP (activation) more efficiently than that of the reverse reaction of replacement of GTP for GDP (deactivation), consistent with prior genetic analysis of CDC25 which indicated a positive role in the activation of Ras. | Guanosine Diphosphate | Ras family guanine nucleotide exchange factor CDC25 | Saccharomyces cerevisiae S288C |
| 3 | This higher affinity of CDC25 for the nucleotide-free form than for either the GDP- or GTP-bound form suggests that CDC25 catalyzes exchange of guanine nucleotides bound to Ras proteins by stabilization of the transitory nucleotide-free state. | Guanosine Diphosphate | Ras family guanine nucleotide exchange factor CDC25 | Saccharomyces cerevisiae S288C |
| 4 | This higher affinity of CDC25 for the nucleotide-free form than for either the GDP- or GTP-bound form suggests that CDC25 catalyzes exchange of guanine nucleotides bound to Ras proteins by stabilization of the transitory nucleotide-free state. | Guanosine Diphosphate | Ras family guanine nucleotide exchange factor CDC25 | Saccharomyces cerevisiae S288C |