Title : Inhibition of dysthrombins Quick I and II by heparin cofactor II and antithrombin.

Pub. Date : 1993 Feb 15

PMID : 8429008






3 Functional Relationships(s)
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1 Heparin cofactor II and antithrombin are plasma serine proteinase inhibitors whose ability to inhibit alpha-thrombin is accelerated by glycosaminoglycans. Glycosaminoglycans coagulation factor II, thrombin Homo sapiens
2 We also found that heparin cofactor II formed a SDS-resistant bimolecular complex with Quick II and alpha-thrombin at similar rates and the rate of complex formation was accelerated in the presence of glycosaminoglycans. Glycosaminoglycans coagulation factor II, thrombin Homo sapiens
3 The importance of heparin cofactor II as a thrombin regulator will depend upon its ability to interact with glycosaminoglycans and the functional availability of thrombin exosites. Glycosaminoglycans coagulation factor II, thrombin Homo sapiens