Title : Interaction of insulin-like growth factor-II and estradiol directs steroidogenesis in the human fetal adrenal toward dehydroepiandrosterone sulfate production.

Pub. Date : 1993 Sep

PMID : 8396578






2 Functional Relationships(s)
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1 Our underlying hypothesis is that estrogen and insulin-like growth factor-II (IGF-II) modulate the steroidogenic response of fetal zone cells to ACTH, driving steroid production toward DHAS rather than cortisol. Steroids insulin like growth factor 2 Homo sapiens
2 These data indicate that IGF-II increases ACTH-stimulated steroid production in fetal zone cells by increasing the expression of key steroidogenic enzymes. Steroids insulin like growth factor 2 Homo sapiens