Pub. Date : 1993 Jun 15
PMID : 8391259
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using the potent tyrosine kinase inhibitor tyrphostin AG-213, we have observed a significant inhibition of aggregation and 5-hydroxytryptamine release; however, this percentage inhibition was lower at high thrombin concentrations. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |
| 2 | On the other hand, tyrphostin treatment of metabolically 32P-labelled platelets significantly inhibited the thrombin-dependent accumulation of PtdIns(3,4)P2, which involves at least a PtdIns 3-kinase and/or a PtdIns3P 4-kinase, whereas the synthesis of phosphatidic acid (PtdOH), a good reflection of the phospholipase C (PLC) activation in platelets, was partially blocked. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |
| 3 | Inositol phosphate production was also inhibited by about 40% when tyrphostin-treated platelets were stimulated with thrombin. | Tyrphostins | coagulation factor II, thrombin | Homo sapiens |