Pub. Date : 1993 Apr 5
PMID : 8385106
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Over a physiologically relevant range of concentrations, GH was found to promote, in 3T3-F442A fibroblasts, rapid changes in the level of tyrosyl phosphorylation of more than 13 proteins. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 2 | At the highest GH concentration employed (500 ng/ml), increased tyrosyl phosphorylation of two proteins, pp121 and pp97, was clearly visible at 1 min, the earliest time tested. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 3 | Increased tyrosyl phosphorylation of a number of other proteins (pp250, pps160-180, pps140-160, pp130, pp90, pp75, pp45, pp42, pp39, and pp36) and decreased tyrosyl phosphorylation of a 140-kDa protein were apparent after 5-10 min of incubation with GH. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 4 | When added to anti-GH antibody immunoprecipitates from GH-treated cells, they inhibited incorporation of 32P from [gamma-32P]ATP into tyrosyl residues in GH receptor complexes. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 5 | When added to anti-GH antibody immunoprecipitates from GH-treated cells, they inhibited incorporation of 32P from [gamma-32P]ATP into tyrosyl residues in GH receptor complexes. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 6 | When added to cells, all three inhibitors blocked all GH-dependent increases in tyrosyl phosphorylation of cellular proteins. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 7 | In contrast, genistein and hydroxy-(2-naphthyl)-methylphosphonic acid, tyrosine kinase inhibitors lacking specificity for the GH receptor-associated kinase, decreased GH-dependent tyrosyl phosphorylation of only a subset of GH-responsive bands and partially blocked GH-dependent activation of MAP kinase. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 8 | In contrast, genistein and hydroxy-(2-naphthyl)-methylphosphonic acid, tyrosine kinase inhibitors lacking specificity for the GH receptor-associated kinase, decreased GH-dependent tyrosyl phosphorylation of only a subset of GH-responsive bands and partially blocked GH-dependent activation of MAP kinase. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 9 | In contrast, genistein and hydroxy-(2-naphthyl)-methylphosphonic acid, tyrosine kinase inhibitors lacking specificity for the GH receptor-associated kinase, decreased GH-dependent tyrosyl phosphorylation of only a subset of GH-responsive bands and partially blocked GH-dependent activation of MAP kinase. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 10 | These data show that increased tyrosyl phosphorylation of specific cellular proteins is a very rapid response to the binding of GH by the cell and most likely involves multiple tyrosine kinases. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 11 | Furthermore, inhibition of the GH receptor-associated tyrosine kinase blocks at least two actions of GH, the stimulation of tyrosyl phosphorylation of multiple proteins and MAP kinase activation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |