Title : Role of calcium channels in spreading depression in rat hippocampal slices.

Pub. Date : 1993 Feb 26

PMID : 8384511






4 Functional Relationships(s)
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1 SD was provoked under control conditions and also when voltage-gated Ca2+ channels were blocked by application of 2 mM Ni2+ or Co2+. SD 0006 carbonic anhydrase 2 Rattus norvegicus
2 When SD was provoked by hypoxia, these treatments significantly increased the latency of SD onset and decreased the amplitudes of the accompanying delta Vo, delta [Ca2+]o and delta [K+]o. Hypoxia-induced SD was never blocked completely, however and delta [Ca2+]o was reduced at most by 50%. SD 0006 carbonic anhydrase 2 Rattus norvegicus
3 When SD was provoked by hypoxia, these treatments significantly increased the latency of SD onset and decreased the amplitudes of the accompanying delta Vo, delta [Ca2+]o and delta [K+]o. Hypoxia-induced SD was never blocked completely, however and delta [Ca2+]o was reduced at most by 50%. SD 0006 carbonic anhydrase 2 Rattus norvegicus
4 When SD was provoked by application of high K+ solution near the recording site, Ni2+ or Co2+ partially suppressed the Vo and [Ca2+]o shifts but did not block SD altogether. SD 0006 carbonic anhydrase 2 Rattus norvegicus