Pub. Date : 1993 Feb 1
PMID : 8381048
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells. | Suramin | insulin like growth factor 2 | Homo sapiens |
| 2 | In parallel, suramin induced the expression of the 6.0-kilobase transcript of insulin-like growth factor II (IGF II) but had no significant effect on transforming growth factor beta 1 mRNA levels in these cells. | Suramin | insulin like growth factor 2 | Homo sapiens |
| 3 | The growth-inhibitory effect of suramin was not mediated through IGF II, since addition of IGF II directly to the medium mildly stimulated the growth of HepG2 cells in a dose-responsive manner. | Suramin | insulin like growth factor 2 | Homo sapiens |