Title : Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

Pub. Date : 1993 Sep 25

PMID : 8376361






1 Functional Relationships(s)
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1 Signal transduction for tumor necrosis factor-alpha and interleukin-1 involves sphingomyelin hydrolysis to ceramide and stimulation of a ceramide-activated serine/threonine protein kinase (Mathias, S., Younes, A., Kan, C., Orlow, I., Joseph, C., and Kolesnick, R. (1993) Science 259, 519-522). Ceramides interleukin 1 alpha Homo sapiens