Title : An immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 (HXB2-Env:Ala 582(-->Thr)) decreases viral neutralization by monoclonal antibodies to the CD4-binding site.

Pub. Date : 1993 Sep

PMID : 8356803






1 Functional Relationships(s)
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1 Furthermore, the ability of 10 human HIV-1-positive sera to block the binding of soluble CD4 to mammalian-recombinant gp120 correlated weakly with their differentiation of neutralization between the wild-type and the Env:Ala582(-->Thr)-mutant virus. Threonine inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens