Pub. Date : 1993 Aug 3
PMID : 8347164
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-CYP2E1 significantly inhibited the metabolism of toluene to benzyl alcohol (BA) by about 50%, in microsomes from 1000 to 4000 ppm toluene-exposed rats, at low substrate concentration (0.2 mM). | Toluene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 2 | Anti-CYP2E1 significantly inhibited the metabolism of toluene to benzyl alcohol (BA) by about 50%, in microsomes from 1000 to 4000 ppm toluene-exposed rats, at low substrate concentration (0.2 mM). | Toluene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 3 | Immunoblot analysis with anti-CYP2E1 and anti-CYP2B1/2 revealed stronger immunoreactive bands in microsomes from rats exposed to more than 1000 and 2000 ppm of toluene, respectively. | Toluene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 4 | These results suggest that toluene induces CYP2E1, CYP2B1/2 and CYP3A1/2, but reduces CYP2C11/6, and has no effect on CYP1A1/2. | Toluene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |