Title : Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition.

Pub. Date : 1977 Jan 25

PMID : 833134






1 Functional Relationships(s)
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1 When cell cultures were incubated with certain oxygenated derivatives of cholesterol which specifically depress 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity (i.e. 25-hydroxycholesterol, 7-ketocholesterol, or 20 alpha-hydroxycholesterol), a number of consequences followed the decline in enzyme activity. 7-ketocholesterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens