PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 833134-2 1977 When cell cultures were incubated with certain oxygenated derivatives of cholesterol which specifically depress 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity (i.e. 25-hydroxycholesterol, 7-ketocholesterol, or 20 alpha-hydroxycholesterol), a number of consequences followed the decline in enzyme activity. 7-ketocholesterol 198-215 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 112-159