Title : Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect.

Pub. Date : 1993 Jul 15

PMID : 8325838






2 Functional Relationships(s)
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1 Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS. Tetradecanoylphorbol Acetate integrin subunit alpha 2b Homo sapiens
2 A central role for GPIIb-IIIa is supported by the near total inability of Glanzmann"s thrombasthenic (type I) platelets to vesiculate in response to thrombin, ADP, collagen, and phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate integrin subunit alpha 2b Homo sapiens