Pub. Date : 1993 Oct 1
PMID : 8293789
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analyses revealed that musk xylene, musk ambrette, isosafrole and BHA induced more strongly cytochrome P450 1A2 (CYP1A2) in microsomes than CYP1A1. | isosafrole | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | Western blot analyses revealed that musk xylene, musk ambrette, isosafrole and BHA induced more strongly cytochrome P450 1A2 (CYP1A2) in microsomes than CYP1A1. | isosafrole | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | These results show that musk xylene, musk ambrette, isosafrole and BHA at the dose level used in this study possess the potency to induce CYP1A2 without remarkable induction of CYP1A1 and phase II enzyme activities as observed for 3-methylcholanthrene, although they have been considered to induce both phase I and phase II drug-metabolizing enzymes at higher doses. | isosafrole | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |