Title : Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.

Pub. Date : 1993 Dec 24

PMID : 8277497






1 Functional Relationships(s)
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1 The naphthoyl analogue of 5-deazaAMT strongly inhibited DHFR from Pneumocystis carinii, Toxoplasma gondii, and rat liver giving IC50 (pM) values of 0.53, 2.1, and 1.6 respectively, but this compound did not inhibit in vitro growth of T. gondii, thus indicating lack of transport. naphthoyl dihydrofolate reductase Mus musculus