Pub. Date : 1994 Jan 7
PMID : 8276857
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition by heparin of thrombin-catalyzed activation of the factor VIII-von Willebrand factor complex. | Heparin | von Willebrand factor | Homo sapiens |
| 2 | In a defined, plasma-free assay of fVIII activation and at physiological ionic strength and pH, heparin inhibited the rate of activation of either human or porcine fVIII by thrombin in either the presence or absence of von Willebrand factor (vWf). | Heparin | von Willebrand factor | Homo sapiens |
| 3 | At plasma concentrations of fVIII (approximately 1 nM) and vWf (approximately 35 nM), the rate of fVIII activation was inhibited by 50% at approximately 0.1 unit/ml heparin, which is below the normal range of heparin concentrations in plasma during therapeutic anticoagulation (0.2-0.7 unit/ml). | Heparin | von Willebrand factor | Homo sapiens |
| 4 | At plasma concentrations of fVIII (approximately 1 nM) and vWf (approximately 35 nM), the rate of fVIII activation was inhibited by 50% at approximately 0.1 unit/ml heparin, which is below the normal range of heparin concentrations in plasma during therapeutic anticoagulation (0.2-0.7 unit/ml). | Heparin | von Willebrand factor | Homo sapiens |
| 5 | We propose that, in addition to catalyzing the inhibition of thrombin and other intrinsic pathway coagulation proteases by antithrombin, heparin functions as an anticoagulant by direct inhibition of the activation of the fVIII-vWf complex by thrombin. | Heparin | von Willebrand factor | Homo sapiens |