Title : Inhibition of protein phosphatases activates P4 promoter of the human insulin-like growth factor II gene through the specific promoter element.

Pub. Date : 1994 Jan 7

PMID : 8276819






4 Functional Relationships(s)
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1 Treatment of A-549 human lung adenocarcinoma cells with okadaic acid increased expression of the IGF-II mRNAs. Okadaic Acid insulin like growth factor 2 Homo sapiens
2 Since the 4.8-kb mRNA is transcribed under the control of human IGF-II P4 promoter, we examined the P4 promoter element responsible for the okadaic acid-mediated transcriptional activation. Okadaic Acid insulin like growth factor 2 Homo sapiens
3 Transfection of IGF-II P4 promoter-chloramphenicol acetyltransferase constructs demonstrated that the effects of okadaic acid on the induction of IGF-II gene expression are mediated through multiple promoter elements, including an Egr-1 consensus element. Okadaic Acid insulin like growth factor 2 Homo sapiens
4 Transfection of IGF-II P4 promoter-chloramphenicol acetyltransferase constructs demonstrated that the effects of okadaic acid on the induction of IGF-II gene expression are mediated through multiple promoter elements, including an Egr-1 consensus element. Okadaic Acid insulin like growth factor 2 Homo sapiens