Title : Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-mediated relaxations.

Pub. Date : 1993 Nov

PMID : 8238588






1 Functional Relationships(s)
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1 In rings of coronary arteries and saphenous veins contracted submaximally with prostaglandin F2 alpha or U46619, alpha-thrombin (0.1-10 nM) caused relaxations that were abolished by treatment with N omega-nitro-L-arginine (L-NNA) or removal of the endothelium, indicating that the relaxations were mediated by endothelium-derived nitric oxide. Dinoprost coagulation factor II, thrombin Homo sapiens