Title : Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole.

Pub. Date : 1993 Dec 1

PMID : 8230282






2 Functional Relationships(s)
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1 PURPOSE: We studied the clinical pharmacology of all-trans RA in cancer patients to determine possible mechanisms of acquired resistance and evaluated the potential for reversal by ketoconazole, an inhibitor of cytochrome-P450 oxidative enzymes. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Ketoconazole attenuates this accelerated catabolism, suggesting that oxidation by cytochrome-P450 enzymes is an important pathway for both constitutive and induced pathways of all-trans RA metabolism. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens