Pub. Date : 1993 Dec 1
PMID : 8230282
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | PURPOSE: We studied the clinical pharmacology of all-trans RA in cancer patients to determine possible mechanisms of acquired resistance and evaluated the potential for reversal by ketoconazole, an inhibitor of cytochrome-P450 oxidative enzymes. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
2 | Ketoconazole attenuates this accelerated catabolism, suggesting that oxidation by cytochrome-P450 enzymes is an important pathway for both constitutive and induced pathways of all-trans RA metabolism. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |