Pub. Date : 1994 Jan
PMID : 8165633
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To investigate the influence of the structure of heparin on its binding to vWF, we compared heparin fractions of different molecular weight (MW) or affinity for antithrombin III (ATIII). | Heparin | von Willebrand factor | Homo sapiens |
| 2 | Using heparin-derived oligosaccharides, we also demonstrated that a minimal chain length of 18 monosaccharides was required for heparin binding to vWF. | Heparin | von Willebrand factor | Homo sapiens |
| 3 | In addition, different fractions with low affinity for ATIII were compared as competitors of 125I-vWF binding to heparin-agarose. | Heparin | von Willebrand factor | Homo sapiens |
| 4 | Thus, heparin interaction with vWF is independent of the presence of the ATIII binding site and is mostly dependent on the length of the heparin chain. | Heparin | von Willebrand factor | Homo sapiens |
| 5 | Thus, heparin interaction with vWF is independent of the presence of the ATIII binding site and is mostly dependent on the length of the heparin chain. | Heparin | von Willebrand factor | Homo sapiens |
| 6 | These data suggest that unfractionated heparin is a more potent inhibitor of vWF-dependent functions than low MW heparin fractions. | Heparin | von Willebrand factor | Homo sapiens |