Title : Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia.

Pub. Date : 1994 Apr 15

PMID : 8161775






1 Functional Relationships(s)
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1 We found that BCR-ABL expression inappropriately prolongs the growth factor-independent survival of CML myeloid progenitors and granulocytes by inhibiting apoptosis, a genetically programmed process of active cell death; inhibition of BCR-ABL expression by antisense oligonucleotides reversed the suppression of apoptosis as well as the enhancement of survival. Oligonucleotides ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens