Title : Ceramide does not mediate the effect of tumour necrosis factor alpha on superoxide generation in human neutrophils.

Pub. Date : 1994 Mar 15

PMID : 8141790






4 Functional Relationships(s)
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1 The effect of tumour necrosis factor alpha (TNF alpha) on superoxide generation in human neutrophils was investigated using the Nitro Blue Tetrazolium reduction assay. Superoxides tumor necrosis factor Homo sapiens
2 TNF alpha stimulated superoxide generation in a time- and concentration-dependent fashion. Superoxides tumor necrosis factor Homo sapiens
3 The maximally effective concentration of TNF alpha for superoxide generation was 10 nM and maximal response was obtained after 15-20 min. Superoxides tumor necrosis factor Homo sapiens
4 These results suggest that TNF alpha stimulates superoxide generation through both the 55 kDa and 75 kDa receptors, but that ceramide does not act as an intracellular mediator for TNF alpha in human neutrophils. Superoxides tumor necrosis factor Homo sapiens