PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8141790-1 1994 The effect of tumour necrosis factor alpha (TNF alpha) on superoxide generation in human neutrophils was investigated using the Nitro Blue Tetrazolium reduction assay. Superoxides 58-68 tumor necrosis factor Homo sapiens 44-53 8141790-2 1994 TNF alpha stimulated superoxide generation in a time- and concentration-dependent fashion. Superoxides 21-31 tumor necrosis factor Homo sapiens 0-9 8141790-3 1994 The maximally effective concentration of TNF alpha for superoxide generation was 10 nM and maximal response was obtained after 15-20 min. Superoxides 55-65 tumor necrosis factor Homo sapiens 41-50 8141790-10 1994 These results suggest that TNF alpha stimulates superoxide generation through both the 55 kDa and 75 kDa receptors, but that ceramide does not act as an intracellular mediator for TNF alpha in human neutrophils. Superoxides 48-58 tumor necrosis factor Homo sapiens 27-36