Title : c-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine lesions in the rat.

Pub. Date : 1993 Mar

PMID : 8098512






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1 We have examined the expression of immediate early genes in central neurons of the rat and now show that a 6-hydroxydopamine-induced axotomy of the dopaminergic nigrostriatal pathway results in a substantial increase in the levels of c-jun (but not c-fos) messenger RNA and protein within neurons of the substantia nigra pars compacta. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus