Title : Activation of procollagenase IV by cytochalasin D and concanavalin A in cultured rat mesangial cells: linkage to cytoskeletal reorganization.

Pub. Date : 1994 Apr

PMID : 8068874






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Cytochalasin D treatment of mesangial cells reduces TIMP-2 expression. Cytochalasin D TIMP metallopeptidase inhibitor 2 Rattus norvegicus
2 It was concluded that cytochalasin D-induced cytoskeletal disruption in mesangial cells may activate procollagenase IV by inhibiting TIMP-2 expression and that there is a concanavalin A-binding site on mesangial cells that is part of a transmembrane signaling system altering mesangial cell cytoskeletal organization and metalloproteinase secretion and activation. Cytochalasin D TIMP metallopeptidase inhibitor 2 Rattus norvegicus