Title : Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

Pub. Date : 1994 Aug 26

PMID : 8063770






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Neomycin, a high affinity ligand of PIP2, inhibits membrane-bound PLD but has no effect on the activity of a detergent-solubilized or partially purified enzyme. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 The addition of PIP2 restores the sensitivity of partially purified PLD to neomycin inhibition, indicating that neomycin blocks membrane PLD activity by binding to endogenous PIP2. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 The addition of PIP2 restores the sensitivity of partially purified PLD to neomycin inhibition, indicating that neomycin blocks membrane PLD activity by binding to endogenous PIP2. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
4 The addition of PIP2 restores the sensitivity of partially purified PLD to neomycin inhibition, indicating that neomycin blocks membrane PLD activity by binding to endogenous PIP2. Neomycin glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens