Title : Changes in rheumatoid factor and monoclonal IgG antibody specificity after site-specific mutations in antigenic region of beta 2-microglobulin.

Pub. Date : 1994 Sep

PMID : 8062449






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Single site-specific mutations at lysine 58 and serine 61 produced a major decrease (50-100%) in reactivity of polyclonal IgM RF with beta 2m. Serine beta-2-microglobulin Homo sapiens
2 Serine at position 61 and tyrosine at 63 also appeared to represent important residues for antigenic determinants reacting with anti-beta 2m mAbs. Serine beta-2-microglobulin Homo sapiens