Protein Name beta-2-microglobulin
Organism Homo sapiens
Gene ID 567
Gene Symbol

B2M

UniProt P61769 (B2MG_HUMAN)
Relationships Total Number of functionally related compound(s) : 657
Total Number of Articles : 1279
Description

beta-2-microglobulin

Gene Summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

synonyms
  • beta-2-microglobulin
  • beta chain of MHC class I molecules
  • beta-2-microglobin
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Properties