Title : Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange.

Pub. Date : 1994 Aug 9

PMID : 8049218






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Rephosphorylation with CK-II restores GTP binding and increases 4-5-fold the activity of GEF in the exchange of eIF-2-bound GDP for free GTP. Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens
2 The rate of GEF-catalyzed exchange of dephosphorylated eIF-2-bound GDP for GTP is approximately 2-fold slower than that with the isolated eIF-2. Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens
3 The rate of GEF-catalyzed exchange of dephosphorylated eIF-2-bound GDP for GTP is approximately 2-fold slower than that with the isolated eIF-2. Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens