Pub. Date : 1994 Jul 22
PMID : 8034626
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rap1A is a GTP-binding protein of the Ras superfamily that is highly abundant in phagocyte membranes. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 2 | Therefore, we have stably transfected human Epstein-Barr virus-transformed B lymphocytes that possess an activable NADPH oxidase complex with cDNAs for mutants of Rap1A "locked" in a GTP-bound (63E) and GDP-bound (17N) state. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 3 | Furthermore, the inhibitory effect of both GTP- as well as GDP-bound mutants indicates that Rap1A functions in a dynamic cycle as opposed to a unidirectional pathway, as is the case for the other NADPH oxidase regulatory GTP-binding protein, Rac. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 4 | Furthermore, the inhibitory effect of both GTP- as well as GDP-bound mutants indicates that Rap1A functions in a dynamic cycle as opposed to a unidirectional pathway, as is the case for the other NADPH oxidase regulatory GTP-binding protein, Rac. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |