Title : Effects of tyrosine-->phenylalanine mutations on auto- and trans-phosphorylation reactions catalyzed by the insulin receptor beta-subunit cytoplasmic domain.

Pub. Date : 1994 Jun

PMID : 8024702






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Effects of tyrosine-->phenylalanine mutations on auto- and trans-phosphorylation reactions catalyzed by the insulin receptor beta-subunit cytoplasmic domain. Phenylalanine insulin receptor Homo sapiens
2 To determine the contribution of these tyrosine phosphorylations to autoactivation of the receptor kinase, we have blocked phosphorylation at specific tyrosine by replacing these tyrosine residues, individually and in combination, with phenylalanine in a soluble 45-kD analog of the cytoplasmic insulin receptor kinase domain (CIRK). Phenylalanine insulin receptor Homo sapiens