Title : Structure-function relationships of rat androgen--binding protein/human sex-hormone binding globulin: the effect of mutagenesis on steroid-binding parameters.

Pub. Date : 1994 Jul

PMID : 8013348






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human SHBG has a higher affinity for steroids and forms a more stable 5 alpha-dihydrotestosterone (DHT) complex (t1/2 = 40 min) than rat epididymal ABP (t1/2 = 5 min) at 0 C. In this study it was found that recombinant wild-type rat ABP/SHBG bound DHT and estradiol with nearly the same affinities as human SHBG, rather than the affinities of rat epididymal ABP. Dihydrotestosterone sex hormone binding globulin Homo sapiens
2 Human SHBG has a higher affinity for steroids and forms a more stable 5 alpha-dihydrotestosterone (DHT) complex (t1/2 = 40 min) than rat epididymal ABP (t1/2 = 5 min) at 0 C. In this study it was found that recombinant wild-type rat ABP/SHBG bound DHT and estradiol with nearly the same affinities as human SHBG, rather than the affinities of rat epididymal ABP. Dihydrotestosterone sex hormone binding globulin Homo sapiens
3 Human SHBG has a higher affinity for steroids and forms a more stable 5 alpha-dihydrotestosterone (DHT) complex (t1/2 = 40 min) than rat epididymal ABP (t1/2 = 5 min) at 0 C. In this study it was found that recombinant wild-type rat ABP/SHBG bound DHT and estradiol with nearly the same affinities as human SHBG, rather than the affinities of rat epididymal ABP. Dihydrotestosterone sex hormone binding globulin Homo sapiens
4 Human SHBG has a higher affinity for steroids and forms a more stable 5 alpha-dihydrotestosterone (DHT) complex (t1/2 = 40 min) than rat epididymal ABP (t1/2 = 5 min) at 0 C. In this study it was found that recombinant wild-type rat ABP/SHBG bound DHT and estradiol with nearly the same affinities as human SHBG, rather than the affinities of rat epididymal ABP. Dihydrotestosterone sex hormone binding globulin Homo sapiens