Title : The high density lipoprotein- and apolipoprotein A-I-induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier disease subjects.

Pub. Date : 1994 Nov 30

PMID : 7999122






2 Functional Relationships(s)
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1 Since this phenotype may in part be caused by a defect in the pathway mediating cholesterol efflux from peripheral cells, we investigated the HDL3-mediated mobilization of cholesterol synthesized de novo from [14C]-mevalonolactone in cultivated fibroblasts from two patients with Tangier disease. Carbon-14 HDL3 Homo sapiens
2 Our results indicate that the HDL3-induced translocation of [14C]-cholesterol from intracellular pools to the plasma membrane and its subsequent secretion into the extracellular medium was approximately 50% less in the cells from the patients than in controls. Carbon-14 HDL3 Homo sapiens