PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7999122-2 1994 Since this phenotype may in part be caused by a defect in the pathway mediating cholesterol efflux from peripheral cells, we investigated the HDL3-mediated mobilization of cholesterol synthesized de novo from [14C]-mevalonolactone in cultivated fibroblasts from two patients with Tangier disease. Carbon-14 210-213 HDL3 Homo sapiens 142-146 7999122-3 1994 Our results indicate that the HDL3-induced translocation of [14C]-cholesterol from intracellular pools to the plasma membrane and its subsequent secretion into the extracellular medium was approximately 50% less in the cells from the patients than in controls. Carbon-14 61-64 HDL3 Homo sapiens 30-34