Title : Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT).

Pub. Date : 1994 Dec 9

PMID : 7996541






1 Functional Relationships(s)
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1 The 5-halo-6-alkoxy(or azido)-5,6-dihydro-3"-azido-3"-deoxythymidines, which differ in configuration at the C-5 and C-6 positions, were synthesized by the regiospecific addition of XR (X = Br, Cl, I; R = alkoxy, azido) to the 5,6-olefinic bond of AZT. 3',5-diazido-2',3'-dideoxyuridine hemolytic complement Mus musculus