Pub. Date : 1994
PMID : 7992230
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exposure to contaminated rice oil containing large doses of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) also resulted in massive elevation of CYP 1A1 in human placenta but formation of DNA adducts directly from this exposure has not previously been reported. | Dibenzofurans, Polychlorinated | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Exposure to contaminated rice oil containing large doses of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) also resulted in massive elevation of CYP 1A1 in human placenta but formation of DNA adducts directly from this exposure has not previously been reported. | Dibenzofurans, Polychlorinated | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | The purpose for comparing the two populations was to test the hypothesis that if CYP 1A1 induction results in the metabolic activation of endogenous compounds, then DNA adducts should also be present in PCB/PCDF exposed tissues exhibiting high CYP 1A1 activity and some of the adducts detected in the placental DNA from smokers may be identified as those derived from the metabolic activation of endogenous compounds. | Dibenzofurans, Polychlorinated | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | The purpose for comparing the two populations was to test the hypothesis that if CYP 1A1 induction results in the metabolic activation of endogenous compounds, then DNA adducts should also be present in PCB/PCDF exposed tissues exhibiting high CYP 1A1 activity and some of the adducts detected in the placental DNA from smokers may be identified as those derived from the metabolic activation of endogenous compounds. | Dibenzofurans, Polychlorinated | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |