Title : A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues.

Pub. Date : 1994 Oct 14

PMID : 7939659






2 Functional Relationships(s)
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1 Variants of RNase A were produced in which the catalytic histidines at positions 12 and 119 were substituted with the unnatural amino acid 4-fluorohistidine, which has a pKa of 3.5 compared to 6.8 for histidine. Histidine ribonuclease A family member 1, pancreatic Homo sapiens
2 Variants of RNase A were produced in which the catalytic histidines at positions 12 and 119 were substituted with the unnatural amino acid 4-fluorohistidine, which has a pKa of 3.5 compared to 6.8 for histidine. Histidine ribonuclease A family member 1, pancreatic Homo sapiens