Protein Name | ribonuclease A family member 1, pancreatic |
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Organism | Homo sapiens |
Gene ID | 6035 |
Gene Symbol | RNASE1 |
UniProt | P07998 (RNAS1_HUMAN), W0UV93 (W0UV93_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
537
Total Number of Articles : 501 |
Description |
ribonuclease A family member 1, pancreatic |
Gene Summary |
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
synonyms |
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Properties | |