Protein Name ribonuclease A family member 1, pancreatic
Organism Homo sapiens
Gene ID 6035
Gene Symbol


UniProt P07998 (RNAS1_HUMAN), W0UV93 (W0UV93_HUMAN)
Relationships Total Number of functionally related compound(s) : 537
Total Number of Articles : 501

ribonuclease A family member 1, pancreatic

Gene Summary

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

  • ribonuclease pancreatic
  • HP-RNase
  • RIB-1
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