Title : Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension.

Pub. Date : 1994 May

PMID : 7930550






3 Functional Relationships(s)
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1 To clarify whether this mechanism participates in glucocorticoid-induced hypertension, we investigated the effect of dexamethasone on the modulation of vascular AT1 receptor messenger RNA (mRNA) expression in rats. Dexamethasone angiotensin II receptor, type 1a Rattus norvegicus
2 METHODS: The effects were studied of administering dexamethasone orally to rats at a dose of 0.1 mg/day on the modulation of the expression of vascular AT1 receptor mRNA and the blood pressure. Dexamethasone angiotensin II receptor, type 1a Rattus norvegicus
3 Before dexamethasone administration the vascular AT1 receptor mRNA was difficult to detect by Northern blot analysis. Dexamethasone angiotensin II receptor, type 1a Rattus norvegicus