Pub. Date : 1994 Oct
PMID : 7926375
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It has been shown in a previous study that TPA induces the expression of the highly inflammatory cytokine, interleukin (IL) -1 alpha, in the epidermis of SENCAR mice. | Tetradecanoylphorbol Acetate | interleukin 1 alpha | Mus musculus |
| 2 | The goal of this study was to investigate the role of IL-1 alpha in several TPA-induced responses in skin. | Tetradecanoylphorbol Acetate | interleukin 1 alpha | Mus musculus |
| 3 | Topical application of TPA (1 microgram) enhanced the production of immunoreactive IL-1 alpha protein, primarily associated with the suprabasal keratinocytes. | Tetradecanoylphorbol Acetate | interleukin 1 alpha | Mus musculus |
| 4 | TPA produced fourfold increases in vascular permeability as measured by Evans blue dye leakage; this effect was prevented by intradermal injection of anti-IL-1 alpha antibody (25-75 micrograms). | Tetradecanoylphorbol Acetate | interleukin 1 alpha | Mus musculus |
| 5 | Furthermore, injected anti-IL-1 alpha antibody significantly reduced (P < 0.001) TPA-induced inflammatory cell infiltration and epidermal hyperplasia. | Tetradecanoylphorbol Acetate | interleukin 1 alpha | Mus musculus |
| 6 | This study suggests that IL-1 alpha directly or indirectly mediates the inflammatory and hyperplastic responses elicited by topical treatment with TPA. | Tetradecanoylphorbol Acetate | interleukin 1 alpha | Mus musculus |