Title : Cross-talk modulation of signal transduction pathways: two mechanisms are involved in the control of tyrosine aminotransferase gene expression by phorbol esters.

Pub. Date : 1994 Apr

PMID : 7914348






2 Functional Relationships(s)
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1 We find that activation of the second messenger pathway leading from protein kinase C to the transcription factor AP-1 by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) impairs induction of the TAT gene both by glucocorticoid hormones and cAMP. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 We find that activation of the second messenger pathway leading from protein kinase C to the transcription factor AP-1 by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) impairs induction of the TAT gene both by glucocorticoid hormones and cAMP. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus