Pub. Date : 1994 Feb 14
PMID : 7909932
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ventral tegmental area (VTA) injections of tyrosine hydroxylase phosphorothioate antisense oligonucleotide suppress operant behavior in rats. | Oligonucleotides | tyrosine hydroxylase | Rattus norvegicus |
| 2 | An antisense oligonucleotide corresponding to the start coding region of rat tyrosine hydroxylase (TH) mRNA, the transcriptional message of the rate limiting enzyme in the metabolic pathway leading to catecholamine synthesis, was constructed and injected into the ventral tegmental area (VTA). | Oligonucleotides | tyrosine hydroxylase | Rattus norvegicus |
| 3 | An antisense oligonucleotide corresponding to the start coding region of rat tyrosine hydroxylase (TH) mRNA, the transcriptional message of the rate limiting enzyme in the metabolic pathway leading to catecholamine synthesis, was constructed and injected into the ventral tegmental area (VTA). | Oligonucleotides | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Accordingly, TH immunoreactivity in the VTA was reduced in comparison to control experiments using mixed bases oligonucleotides. | Oligonucleotides | tyrosine hydroxylase | Rattus norvegicus |