Title : Nicotine increases expression of tyrosine hydroxylase gene. Involvement of protein kinase A-mediated pathway.

Pub. Date : 1993 Nov 5

PMID : 7901211






3 Functional Relationships(s)
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1 Deletion analysis of the 5" promoter region of the TH gene showed that the region containing a cyclic AMP/calcium regulatory element is sufficient for the nicotinic induction of TH. Cyclic AMP tyrosine hydroxylase Rattus norvegicus
2 Deletion analysis of the 5" promoter region of the TH gene showed that the region containing a cyclic AMP/calcium regulatory element is sufficient for the nicotinic induction of TH. Cyclic AMP tyrosine hydroxylase Rattus norvegicus
3 These results suggest that a cAMP-mediated pathway plays a crucial role in the long term nicotine-induced activation of the TH gene. Cyclic AMP tyrosine hydroxylase Rattus norvegicus