Pub. Date : 1993 Nov 5
PMID : 7901211
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine increases expression of tyrosine hydroxylase gene. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 2 | Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 3 | We investigated the effect of long term treatment with nicotine on TH and DBH gene expression in rat PC12 pheochromocytoma cells. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Nicotine treatment for 1-2 days increased both the TH and DBH mRNA levels. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 5 | The effect of nicotine on TH mRNA seems to be transcriptionally mediated. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 6 | These results suggest that a cAMP-mediated pathway plays a crucial role in the long term nicotine-induced activation of the TH gene. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |