Title : Interleukin-13 inhibits protein kinase C-triggered respiratory burst in human monocytes. Role of calcium and cyclic AMP.

Pub. Date : 1995 Mar 10

PMID : 7890616






4 Functional Relationships(s)
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1 We show here, the inhibitory effect of IL-13 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-triggered reactive oxygen intermediate production in human monocytes and the signals involved in this response. Tetradecanoylphorbol Acetate interleukin 13 Homo sapiens
2 We show here, the inhibitory effect of IL-13 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-triggered reactive oxygen intermediate production in human monocytes and the signals involved in this response. Tetradecanoylphorbol Acetate interleukin 13 Homo sapiens
3 Metabolic inhibitors were used to relate the first steps in signaling pathways to the inhibitory effect of IL-13 on TPA-triggered reactive oxygen intermediate production. Tetradecanoylphorbol Acetate interleukin 13 Homo sapiens
4 Altogether these observations indicate that modulatory effect of IL-13 on the TPA-induced oxidative burst is the result of the intracellular cAMP accumulation through an inositol 1,4,5-trisphosphate-induced Ca2+ mobilization-dependent pathway. Tetradecanoylphorbol Acetate interleukin 13 Homo sapiens